Constructs for non-union bone defects

We work in a therapeutic solution to address unmet clinical needs in bone regeneration and vascularisation in non-union bone defects. Our approach is based on the use of synthetic functional materials polymerised on the surface of 3D structural scaffolds, that allow the safe and effective presentation of GF rhBMP-2.

We are analyzing rhBMP-2 binding and presentation, the effect of rhBMP-2 presentation on MSC proliferation and differentiation, and we are evaluating the engineered constructs in bone repair in animal models in collaboration with Prof. Andrés García (Georgia Tech, Atlanta).

rhBMP-2 has been particularly well studied for the regeneration of bone and it has been FDA approved for clinical use adsorbed onto a collagen sponge a decade ago. This approved products use supraphysiological BMP-2 concentrations that have led to adverse effects. Our systems are incorporating BMP-2 in much lower doses.

This area of research is performed in close collaboration with other teams at the School of Engineering (Dr. Nikolaj Gadegaard and Prof. Elizabeth Tanner), at the Centre for Cell Engineering (Dr. Matthew Dalby and Dr. Mathis Riehle), other researchers at the University of Glasgow (Prof. Faisal Ahmed, Mr Dominic Meek, Dr. Richard Burchmore and Dr. Karl Burgess) and at the UK Regenerative Medicine Platform Hub in Acellular Technologies (Prof. Kevin Shakesheff  and Prof. Brigitte Scammell)