Engineering cellular environments to promote tissue healing involves the design of complex systems that combine materials, extracellular matrix (ECM) proteins and growth factors (GF). We exploit synergistic interactions between material surfaces, natural and synthetic ECM and GFs to control cell behaviour and tissue repair.
We study the role of surface mobility in cell – material interactions and stem cell fate, and we engineer these synergistic microenvironments to direct cell and stem cell fate.
We are also exploring the enhanced presentation and activity of GFs during tissue healing, in different tissue repair platforms, and are investigating the bioactivity of the different systems in vitro and in vivo. These systems will allow not only enhanced activity of GFs compared to soluble administration, but also to reduce GFs doses, improving safety and cost effectiveness.