Our ongoing collaboration with veterinary surgeons (Small Animal Hospital at the University of Glasgow) has produced a promising and very happy result. A bone-growth technology developed and patented at our lab, that allows the effective use of very low doses of bone morphogenetic protein BMP-2, was used to heal a 2cm critical defect in the right foreleg of a Munsterlander dog called Eva.
The recovery of Eva after her surgery has been reported by several media sources during the last week. Some of them are pictured below.
The technology is being developed for human trials in a project funded by charity Find A Better Way, to produce ex-vivo bone tissue for trauma surgeons when treating landmine blast survivors.
Dr Ralf Richter visited the University of Glasgow last Tuesday and delivered a talk at our weekly Biomaterials Seminar. He presented his work over the years with extracellular matrix polysaccharides and soft biological hydrogels, trying to understand how they function in health and disease.
Extracellular matrix polysaccharides such as hyaluronan (HA) and other glycosaminoglycans are vital to the communication of cells in multicellular organisms, and are involved in many physiological and pathological processes including inflammation, fertilization, neuronal plasticity, tumor development and atherosclerosis. How these molecules work remains largely elusive because they do not obey classical structure-function relationships and are challenging to study with conventional structural and biological techniques. They lack a well-defined secondary structure and much of their functions rely on the formation of dynamic and disordered supramolecular assemblies (hydrogel-like materials).
To study these molecules and materials, Richter’s lab has developed in vitro model systems with tunable complexity, like in vitro reconstituted HA matrices, or self-assembly of purified biomolecules on solid supports. These model systems are amenable to quantitative analysis, and allow a better understanding of how the properties of the individual molecules and interactions translate into supramolecular assemblies with distinct physico-chemical properties, and how new phenomena emerge from multivalent interactions. For instance with this models the Richter Lab have also shown that matrix-bound chemokines can promote cell adhesion even in the absence of any established cell adhesion ligand, and potentiate cell adhesion when such ligands are presented.
Dr Richter is a Associate Professor at University of Leeds. He has been to several European countries in his career. From his MSc in Sweden, PhD in France in 2004, to research done in Germany and Spain. More information on his research interests and projects can be found here.
A doodle summary of the presentation by Dr Mathis Riehle can be found here.
Dr Mathis Riehle has uploaded the full set of his sketchnotes of the talks in the “Bioengineering for Cancer” workshop that took place last November 2016 at the Beatson Institute for Cancer Research.
Check his website for many more amazing doodles!
Next Thursday 16th Feb Professor Salmeron-Sanchez will be in Imperial College London to talk about “Protein-based microenvironments to control stem cell fate“
A FEBS Workshop with the title “Biological Surfaces and Interfaces: Interface Dynamics” will take place from the 2nd July to 7th July 2017 in Hotel Eden Roc, Sant Feliu de Guixols, Catalonia, Spain.
Prof Manuel Salmerón-Sánchez (University of Glasgow, UK) and Ilya Reviakine (University of Washington, USA) will chair the event.
Find all the information – programme, abstract submission and registration instructions – in this link.
SCOPE OF THE WORKSHOP
This conference covers research into the dynamics of biological interfaces. The goal of the meeting is to bring together researchers from diverse disciplines who are actively working on this topic and to engage young scientists at the doctoral and postdoctoral level, nucleating new ideas and new directions.
Thomas BARKER – Dynamic molecular complexes in cell interaction with the ECM
Timo BETZ – Activity at the border: How active cytoskeleton-membrane interaction control cell mechanics
Matthew J. DALBY – Nanoscale control of stem cell differentiation
Aranzazu DEL CAMPO – Light-triggered dynamic biointerfaces
Reinhard FÄSSLER – Mechanosensing via cell-matrix adhesions
Andres J. GARCIA – Biofunctional dynamic hydrogels for tissue repair
Maria GARCIA-PARAJO –
Delphine GOURDON – Fibronectin mechanobiology regulates tumorigenesis
Pamela HABIBOVIC – Design-driven biomaterials development: decoupling and recombining individual material properties
Viola VOGEL – Mechanobiology: the art of forming and forcing bonds to break
Peter JÖNSSON – Studying intermolecular interactions between membrane-anchored proteins using hydrodynamic forces
Laura MACHESKY – IUBMB Lecturer – Role of the actin cytoskeleton, matrix and stiffness in cancer invasion and metastasis
Yukiko MATSUNAGA – Actin cytoskeleton and cell migration in cancer
Catherine PICART – Engineered biomaterials coatings for the control of cell fate: from molecular mechanisms to regenerative medicine
Ralf RICHTER – Many weak interactions make a difference – from superselective targeting of cells to macromolecular transport across the nuclear envelope
Kevin SHAKESHEFF – Thermoresponsive materials as injectable matrices for regenerative medicine
Molly STEVENS – Exploring and engineering the cell/material interface
Masaru TANAKA – Interfacial water at the cell/protein/material interface
Xavier TREPAT– Collective guidance of cell migration and invasion
Tobias WEIDNER – Protein control of hard and soft tissue – a molecular view
The UofG Engineering Undergraduate Course and PhD information Event will take place this Wednesday 11th January in rooms 427A and B of the James Watt (South) Building. Doors open 3pm – 6pm. Several of our PhD students and Research Associates will be around. We have prepared two new posters that present the current research activity of MiMe.
Professors Matt Dalby and Manuel Salmeron-Sanchez will be giving a Joint Keynote Presentation titled “Working together – growth factor and nanovibrational technologies” this next Thursday 12th January at the 7th RSC Biomaterials Chemistry Special Interest Group Annual Conference at Ulster University, Northern Ireland. More info about the event here.
Prof Salmeron-Sanchez was interviewed on BBC Radio 4 and BBC World Service this morning. He talked about our recently awarded Find A Better Way grant. This is a five year long regenerative medicine project based in Glasgow to develop bone tissue grafts, grown in-vitro in the lab, ready to be delivered to the surgeon. The ultimate goal is to allow treatment of landmine and blast injuries and reconstruction of lost tissue beyond what is possible now.
Listen to the 4-5 minutes interviews in these links:
Radio 4: http://www.pressdata.co.uk/viewbroadcast.asp?a_id=11638403
World Service: http://www.pressdata.co.uk/viewbroadcast.asp?a_id=11638717
Two Postdoctoral and a Project Manager position are now open with deadline for applications 08/01/2017, to work based in the Division of Biomedical Engineering at the University of Glasgow. These jobs are part of our five year cross-disciplinary EPSRC Programme Grant with partners in the Universities of Glasgow, Nottingham and Imperial College.
Links to the job alerts and application instructions below:
Programme Grant Project Manager ref 015131
Programme Grant Research Assistant / Associate ref 015129
Programme Grant Research Assistant / Associate ref 015128
A feature article has been published by Professors Manuel Salmerón-Sánchez and
The paper – Synergistic growth factor microenvironments. Chem. Commun., 2016, 52, 13327-13336 – is also accompanied by a contribution to the cover of ChemComm, Issue 91, 2016, thanks to the art skills of Dr. Aleixandre Rodrigo-Navarro.
The paper describes current advances with the presentation of growth factors (GF) bound to surfaces from a solid-phase state rather than in soluble form, recapitulating the way the extracellular matrix (ECM) binds GFs. This more effective presentation allows GFs to work in cooperation with integrins and enhance GF signalling due to the crosstalk between both receptors. This knowledge has been used to engineer microenvironments that target simultaneous integrin and GF receptor engagement seeking to maximise GF effects in vitro (e.g. in terms of stem cell differentiation) but also tissue repair in vivo (e.g. bone regeneration and wound healing).