We have an invited speaker for our next biomaterials seminar (Tuesday 9th). Dr Dimitrios A. Lamprou is Lecturer in Pharmaceutical Sciences at the University of Strathclyde. He is also Director of the MSc in Advanced Pharmaceutical Manufacturing; Director of the Wolfson Foundation / RPIF Funded Pharmaceutical Surfaces Laboratory; Co-I at EPSRC CMAC Centre.
His talk will touch on three lines of research related to biomaterials for tissue engineering and pharmaceutical applications, using advanced techniques to characterise surfaces and interfaces (e.g. Bio FastScan, AFM, Rheology with IR and Microscopy, Raman Confocal Microscopy, ToF-SIMS, μCT, μCAG).
The first part of the talk will be about polymers that are currently used for biomaterial applications but are still associated with side effects (e.g. biofouling), and how this can be reduced if compounds that oppose these side effects are introduced to the polymers. In an effort to exploit such activities, isatin derivatives were synthesised and added to these biocompatible polymers. The resultant films were characterised with advanced techniques and the cytotoxicity and effect on cell proliferation of the surfaces was also investigated.
The second part will focus on the preparation of drug-loaded polymeric electrospun nanofibers for Tissue Engineering applications. The purpose of this study is to examine any potential effects, chemical and mechanically, of drug-loaded electrospun nanofiber scaffolds. Biodegradable polyesters that commonly used in biomedical applications for controlled release and targeted drug delivery was loaded and electrospun with two different types of drugs. The electrospun fibres were then characterised through various methods in order to measure the drug efficacy and antibacterial properties, and investigate any changes in mechanical and chemical properties.
Finally the used of Hydrogels for drug delivery applications will be discussed. Hydrogels have been widely studied as potential carriers for drug delivery and tissue engineering applications. To advance applications of hydrogels in the biomedical field, careful design of the hydrogel materials is critically important, and applications of current hydrogels as drug delivery tools are limited by their hydrophilic nature, which prevents their use as drug delivery systems for hydrophobic drugs because of a rapid drug release in the initial phase. Therefore, controlling the release rates of hydrophobic and hydrophilic molecules through various hydrogels is crucial. We have explored the release profile of hydrophilic and hydrophobic drugs through injectable self-assembling peptide hydrogel (drug-in-gel system) and combined these with liposomes.